Klion-D 100 is a combined medicatiom intended for intravaginal use. The active substances Klion-D are Metronidazole and Miconazole.
Metronidazole is an antiprotozoal and antimicrobial drug.
Metronidazole is effective against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia lamblia, obligate anaerobes Bacteroides spp. (Including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens), Gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.).
In the presence of mixed flora (aerobes and anaerobes), Metronidazole effective acts synergistically with antibiotics against aerobes.
Miconazole is an effective antimitotic medication which exerts its action primarily on dermatophytes and yeast fungi.
On intravaginal application Miconazole is active primarily against Candida albicans.
Miconazole inhibits ergosterol biosynthesis in fungi and changes the composition of other lipid components in the membrane, which leads to the death of fungal cells. Miconazole does not change the composition of normal microflora and the pH of the vagina.
Indications: treatment of mixed etiology vaginitis caused simultaneously by Trichomonas spp. and Candida spp.
- increased individual sensitivity to the components of the drug
- pregnancy (I trimester)
- organic lesions of the central nervous system (including epilepsy)
- liver failure
- children's age (up to 12 years)
Packing: 10 vaginal tablets 100 + 100 mg